Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp.

The study aims to investigated the antioxidant activities, phenolic compounds, acetylcholinesterase enzyme inhbition and cytotoxic effects of two different Artemisia spp. (Artemisia dracunculus L. dracunculoides Pursh) cultivated in Turkey organically, for first time. Total phenolic, total flavonoid contents plants determined spectrophotometrically while activity DPPH, CUPRAC, FRAP was using colorimetric method. And also inhibition anti-cancer in-vitro aganist human melanoma (VMM917, CRL-3232), lung carcinoma (A549, CCL-185) and, normal fibroblast (hGF, PCS-201-018) cells were studied. (225-324 mgGAE/g sample) (0.066-0.085 mgQAE/g sample), (DPPH (1.371-1.655 mg/mL), CUPRAC (0.246-0.344 µM CTEAC) (462.133-726.661 CTEAC)). A. extracts inhibited 40.09±0.65%, 39.48±3.68% activity. It that demonstrated selective effect on cytotoxicity A549 hGF cells.